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The biological processes associated with these human liver proteins identified by PANTHER GO Slim analysis, include but are not limited to, iron ion transport, heme metabolic process, intracellular iron ion homeostasis, tricarboxylic acid cycle, transition metal ion transport, complement activation, and anti-bacterial humoral immune response

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Similarly, lepodisiran has shown well-tolerated and dose-dependent reductions in serum Lp(a) concentrations, with a Phase III trial currently recruiting participants and expected to be completed by 2029 (NCT06292013 and NCT04914546)

The therapeutic effects of the compounds were found to be comparable between143B and K7M2 cells